• This raises an important question

  2024-11-29

  

  This raises an important question: May the lack of ethnolinguistic theories and of explicit references to language be related to the lack of contact with other groups and their languages? For the past few centuries at least, the Aché seem to have been culturally and linguistically isolated (Hill and

• The hypothalamic pituitary adrenal HPA axis is a neuroendocr

  2024-11-29

  

  The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that is central to regulating responses to stress (Palazidou, 2012). In older persons, a high dysfunction of the HPA axis is observed (Otte et al., 2005) which may be enhanced by stimulatory effects of genes involved in the axi

• br In patients with spina bifida and spinal cord

  2024-11-29

  

  In patients with spina bifida and spinal cord injury, fecal incontinence is a serious issue that can impair activities of daily living and patient self-esteem. To address this Malone et al. first described the Antegrade Continence Enema (ACE) procedure in 1990 [1], which achieves continence by all

• br Conclusion The HT receptor family is complex

  2024-11-29

  

  Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless Picrotoxin (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological function); molecular biolog

• br Materials and methods br Results br Discussion

  2024-11-29

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• In Rainey et al published the results of a

  2024-11-28

  

  In 2008, Rainey et al. published the results of a targeted compound library screen for potential inhibitors of the ATM kinase. In this study, the compound CP466722 was identified as a highly selective and rapidly reversible ATM inhibitor, which did not inhibit PI3K or related PIKK family members. Mo

• It has also been reported that defects in ATM

  2024-11-28

  

  It has also been reported that defects in ATM or ATR signalling are synthetically lethal with PARP inhibition (Turner et al., 2008, Peasland et al., 2011, Yap et al., 2011, Michels et al., 2014), suggesting that combined inhibition of PARP and ATM or ATR may be an effective therapeutic strategy. In

• We designed SSOs that block APP exon

  2024-11-28

  

  We designed SSOs that block APP exon 17 splicing and induce the production of an alternatively spliced APP mRNA lacking exon 17 (APPΔex17). APPΔex17 mRNA encodes an APP protein isoform that lacks 49 WAY-262611 including the γ-secretase cleavage sites that give rise to the toxic, AD-associated Aβ42

• The synthetic adipoR agonists AdipoRon and are

  2024-11-28

  

  The synthetic adipoR agonists, AdipoRon (1) and 112254 (2), are both detectable in human plasma [18]. However, with increasing knowledge about their metabolism [19], a method for detection from human urine is conceivable and would be preferred given the easier accessibility and greater frequency of

• br Endocytosis of AdipoR Surface

  2024-11-28

  

  Endocytosis of AdipoR1 Surface receptor activity may be shut down by endocytic uptake and subsequent lysosomal degradation of the proteins [20]. Clathrin-dependent endocytosis (CDE) has been extensively studied and internalization from the plasma membrane is mediated through clathrin-coated pits

• NSAIDs induce gastrointestinal toxicity and

  2024-11-27

  

  NSAIDs induce gastrointestinal toxicity and evoke Cefepime Dihydrochloride Monohydrate by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001;

• GNE-7915 br Discussion Here we focused

  2024-11-27

  

  Discussion Here, we focused on seven plant alkaloids extracted from yokukansan. These alkaloids individually inhibited 5-HT-mediated 5-HT3A and 5-HT3AB receptor currents weakly. Simultaneous administration of these alkaloids, however, inhibited the 5-HT3A and 5-HT3AB receptor currents strongly.

• Fig A shows a schematic representation of histological resul

  2024-11-27

  

  Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the

• In order to increase the oral bioavailability

  2024-11-27

  

  In order to increase the oral bioavailability, abiraterone (157) is being used in the form of its 3β-acetoxy prodrug, abiraterone acetate (156). In spite of the fact that high-fat meals increase the oral bromocriptine mesylate of abiraterone acetate (156), it is recommended that this drug should be

• At first the APC is a

  2024-11-27

  

  At first, the APC is a 310kDa protein divided into three domains such as N-terminal, central core and C-terminal domain [102], plays a major role to regulate the Wnt signaling pathway in human cancer by translating β-catenin from the Ezatiostat receptor to the nucleus [103]. The SIRT1 regulates the

15238 records 12/1016 page Previous Next First page 上5页 1112131415 下5页 Last page