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The transcription factor activator protein AP is a redox
2025-01-18
The transcription factor activator protein-1 (AP-1) is a redox-sensitive transcription factor whose activity is controlled by agents that perturb intracellular thiol concentrations [10,11]. AP-1 is mainly composed of Jun, Fos, and ATF protein dimers [12,13]. AP-1 mediates the regulation of numerous
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Besides above mentioned UV visible and fluorescence spectros
2025-01-18
Besides above-mentioned UV–visible and fluorescence spectroscopy methods, electron paramagnetic resonance (EPR) spectroscopy, the only analytical method that detect compounds having unpaired electrons known as free radicals, was rarely used in antioxidant capacity measurement (Amarowicz et al., 2004
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br Conclusions br Acknowledgments br Introduction The surfac
2025-01-18
Conclusions Acknowledgments Introduction The surface water bodies are affected by effluents containing pollutants from wastewater treatment plants, storm water overflows and run-off from non-point sources like agricultural land and urban city surfaces. This relates to land-based sources occ
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br Eprosartan The AT R antagonist eprosartan is
2025-01-18
Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Ac-Endothelin-1 (16-21), human and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebro
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br Materials and methods br Results br
2025-01-18
Materials and methods Results Discussion Prostate cancer is the most common cancer in men in the United States and the second leading cause of cancer death. Therapeutic interventions include mainly: radical prostatectomy or radiation therapy (RT), with or without androgen deprivation therap
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Various compounds have been designed to
2025-01-17
Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic Caspase-4 Colorimetric Assay Kit synthesis moiety, for example, 3-thiazolidineacetic acid derivative, wh
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br Conclusion br Conflict of
2025-01-17
Conclusion Conflict of interest Introduction Oral cancer may originate from lips, lower and upper alveolar ridges, hard palate, sublingual region, buccal mucosa, anterior two-thirds of the tongue as well as retromolar trigone and floor of the mouth (World Health Organization, 2013). As the
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Microbe derived ligands can also activate AHR Malassezia
2025-01-17
Microbe-derived ligands can also activate AHR. Malassezia, a commensal yeast in human skin, can metabolize tryptophan into several AHR activating compounds including FICZ and ICZ [59]. Lactobacillus converts tryptophan into indole-3-aldehyde (IAld), which can activate AHR and promote IL-22 productio
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br Conflict of interest br Acknowledgement This study
2025-01-17
Conflict of interest Acknowledgement This study was supported by a grant from University Grants Commission - Basic Scientific Research (UGC-BSR), New Delhi, India (UGC-BSR No:F-7-115/2007). Introduction The G protein-coupled receptors activated by extracellular adenosine (Ado), called Aden
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Previous reports indicate that the expression
2025-01-17
Previous reports indicate that the expression of AChRs and their clustering on myotubes are critical factors required to induce contacts on muscle fibers in a natural biological system [14], [15], [16], [17], [18], [19]. For instance, in NMJ development in the mouse, AChRs are pre-patterned at sites
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Hepatic steatosis reversal br Experimental section br Result
2025-01-17
Experimental section Results and discussion Conclusion In the present study, 3a,8a-dihydroxy-8-oxo-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazol-2(1H)-iminium chloride (3) has been synthesized and characterized by spectral studies and single crystal X-ray crystallography. DFT calculations have
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While the direct effects of ARI lead to a dramatic
2025-01-17
While the direct effects of 5-ARI lead to a dramatic HIF-PH inhibitor in serum DHT levels, other laboratory values are also affected by 5-ARI use. Serum testosterone elevations are known to occur with both finasteride and dutasteride use, but values will typically remain within the normal laborator
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In plants altered expression of Aurora
2025-01-17
In plants, altered expression of Aurora kinases results in impaired meiotic divisions followed by the formation of aneuploid or polyploid progenies [21]. This observation is interesting from an evolutionary point of view because it can be assumed that, during evolution, the influence of biotic and a
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We next sought to determine the
2025-01-17
We next sought to determine the kinase responsible for IR-induced phosphorylation of 53BP1. Because the sites under investigation all lie in a consensus sequence for ATM, ATR and DNA-PK, that are all activated by IR, the involvement of each of these kinases was investigated. Preincubation of PRL-3 I
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br Conclusions In the current study
2025-01-17
Conclusions In the current study, we found that the exposure of maduramicin to chicken myocardial 2-D08 mg results in cellular damage and even death via the induction of apoptosis. Maduramicin upregulated the expression of apoptotic genes and activated caspase cascades, which were accompanied by
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