• Treatment and control for IBD are targeted to

  2022-10-10

  

  Treatment and control for IBD are targeted to identify and eliminate the cause if possible, decrease intestinal inflammation, reduce diarrhea and vomiting, improve appetite, and promote weight gain. Methods include dietary manipulation with or without concurrent medical therapy such as corticosteroi

• There are several limitations in

  2022-10-10

  

  There are several limitations in our study. First, only the naturally occurring resistance-associated mutations in patients coinfected with HIV/HCV Lopinavir receptor 1b were analyzed. The result was only applicable to HCV genotype 1b, but not the HCV genotype 1a patients. We did not analyze the ef

• br Experimental br Acknowledgment br Introduction Hepatitis

  2022-10-10

  

  Experimental Acknowledgment Introduction Hepatitis C virus (HCV) belongs to Flaviviridae, is a blood-borne pathogen which infects about 180 million individuals throughout the world; most of the cases lead to end stage liver diseases, fibrosis, cirrhosis and hepatocellular carcinoma (Choo et

• Aurora kinase B AURKB and haploid cell

  2022-10-10

  

  Aurora kinase B (AURKB) and haploid cell-specific protein kinase (Haspin) are two well-known participants in N-terminal histone H3 phosphorylations during mitosis. A related role played by these kinases relates to the fact that AURKB is activated by Haspin promoted phosphorylation at T3. Irrespectiv

• br Introduction The signaling molecule nitric oxide NO

  2022-10-10

  

  Introduction The signaling molecule nitric oxide (NO) plays an essential role in vessel homeostasis by initiating vasodilation [1], [2], [3]. After biosynthesis in endothelial cells, NO diffuses into the subjacent smooth muscle layer to reach its target enzyme, soluble guanylyl cyclase (sGC, EC 4

• Screening of the compounds allowed for a number of

  2022-10-10

  

  Screening of the compounds allowed for a number of interesting SAR observations. First of all, pyridyl analogue demonstrated that a pyridine ring would be beneficial for both log as well as increasing the potency (entry 2 versus entry 1). Electron-poor aryl groups next to the oxadiazolone were detr

• In this study with the use of C

  2022-10-09

  

  In this study, with the use of 13C515N2-labeled glutamine, we observed that 13C515N2-labeled glutamine produces a wide range of NAAG isotopologues and its precursors: NAA and glutamate. The NAAG production from glutamine is consistently more elevated in MYC-ON lymphoma and OVCAR4 compared to MYC-OFF

• As a part of our continuing efforts towards discovery of

  2022-10-09

  

  As a part of our continuing efforts towards discovery of new class of compounds against different therapeutic areas and based on the literature reports, we designed a dual pharmacophore which possess a long aliphatic chain of free fatty acids and a phenyl propanoid part of known GPR40 agonists. Here

• ICH induced striatal lesion produced a

  2022-10-09

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino Tacalcitol transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia

• ICH induced striatal lesion produced a

  2022-10-09

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino Tacalcitol transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia

• ICH induced striatal lesion produced a

  2022-10-09

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino Tacalcitol transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia

• Genetic disruption or pharmacologic inhibition of the hepati

  2022-10-09

  

  Genetic disruption or pharmacologic inhibition of the hepatic glucagon pathway has invariably been shown to increase pancreatic α cell mass. This has been observed in glucagon receptor (GCGR) knockout (Gcgr−/−) mice (Gelling et al., 2003), glucagon knockout mice (Hayashi et al., 2009), prohormone co

• br Calcium permeability pathway It has been demonstrated tha

  2022-10-09

  

  Calcium permeability pathway It has been demonstrated that physiological shear stress in the circulation causes a reversible increase in Ca2+ permeability [29], [30], [31], [32], [33] and electrophysiological evidence has been recently reported for transient activation of the Ca2+-sensitive K+ ch

• There is increasing evidence that Cxs

  2022-10-09

  

  There is increasing evidence that Cxs in astrocytes may play a role in several models of brain pathologies. Interestingly their roles are at the moment more considered through their hemichannel function (Bennett et al., 2012; Bosch and Kielian, 2014; Davidson et al., 2013; Orellana et al., 2016; Kim

• The feasibility of using the Fas Fas

  2022-10-08

  

  The feasibility of using the Fas/Fas ligand (FasL) system to target vascular progenitor apoptosis contributing to intimal hyperplasia has been shown in many studies [[18], [19], [20], [21], [22], [23], [24]]. Fas receptor, a member of tissue necrosis factor family, is a death receptor that initiates

15409 records 364/1028 page Previous Next First page 上5页 361362363364365 下5页 Last page