• cki Phylogenetic analysis of the secretin like hormones yiel

  2022-07-16

  

  Phylogenetic analysis of the secretin-like hormones yields poorly supported trees due to the short length of their peptide sequences (Dores et al., 1996). However, phylogenetic analyses typically show that the secretin-like peptides encoded by the proglucagon (glucagon, GLP-1 and GLP-2) and GIP cki

• br Experimental br Results and discussion br

  2022-07-16

  

  Experimental Results and discussion Conclusion In conclusion, four bisnaphthalimides have been investigated for their potential G-quadruplex binding. The compounds 3a, 3b and 5b display high affinity for telomeric and oncogenic G-quadruplexes. On the other hand, 5a only show high affinity f

• G quadruplex structures can be resolved by helicases

  2022-07-16

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer 5-fluorocytosine mg [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and disco

• The metal nanoparticles of gold Au silver Ag Platinum Pt

  2022-07-15

  

  The metal nanoparticles of gold (Au), silver (Ag), Platinum (Pt), Palladium (Pd) and/or their composites are also being widely used to develop electrochemical sensors because of their unique advantages such as (i) ease in immobilization of receptor molecules, (ii) catalysis of electrochemical reacti

• br Introduction Local anesthetics LAs are a set of

  2022-07-15

  

  Introduction Local anesthetics (LAs) are a set of common medicines used for pain management in clinical settings. Up to now, LAs have been extensively used for peripheral nerve blocks, interventional spinal procedures, and epidural anesthesia [1]. In addition to their anesthetic and analgesic eff

• In the present study we focused

  2022-07-15

  

  In the present study, we focused on a role of the C-terminal segment in GCAP2 using two chimeric proteins, in which the C-terminal segment of GCAP2 was either replaced by the corresponding sequence of recoverin (chimera GR) or transferred into recoverin (chimera RG). We have monitored Ca-dependent c

• There are important questions that remain to

  2022-07-15

  

  There are important questions that remain to be answered. How does Rap2a protein affect NF-κB activation? Why do Rap2a silencing and overexpression results to the identical hampered NF-κB activation phenotype? Overexpression experiments have demonstrated that atypical κB-Ras GTPases could inhibit NF

• While published data around the functional significance

  2022-07-15

  

  While published data around the functional significance of GPR84 are quite sparse, details of signaling pathways initiated by the receptor are even more limited, including in recombinant systems. In recombinant cells, GPR84 activation reportedly leads to Gi pathway activation, resulting in pertussis

• Finally LC ESI MS MS was applied to explore

  2022-07-15

  

  Finally, LC-ESI-MS/MS was applied to explore the effects of increased fT4 levels 4 and 8 weeks after induced thyrotoxicosis and have revealed an upregulation of proteins involved in blood coagulation, thus providing a clear association [126]. Conclusions Introduction Diabetes mellitus (DM) ha

• Clotrimazole br Methods br Results br Discussion Our

  2022-07-15

  

  Methods Results Discussion Our results show that the DRG and the spinal cord express significant amount of GPR35, a previously orphan Gi protein coupled receptor whose stimulation with zaprinast or with KYNA may reduce inflammatory pain. The receptor is also expressed in primary cultures of

• br GPR is a class A GPCR expressed

  2022-07-15

  

  GPR119 is a class A GPCR expressed on pancreatic β-cells and certain enteroendocrine Compstatin which upon activation with an agonist, increases insulin secretion in response to rising glucose levels. Mechanistically, this insulinotropic effect is bifurcated involving both GPR119-mediated β-cell

• br TGR agonists current developments and future landscape Th

  2022-07-15

  

  TGR5 agonists: current developments and future landscape The amphipathic nature of bile acids is crucial in aiding the digestion and bromophenol blue of vitamins and fats. With the emerging roles of bile acids in the regulation of energy and glucose homeostasis through TGR5, the pharmaceutical i

• 2-MeOE2 Elevated methylglyoxal levels also contribute to car

  2022-07-15

  

  Elevated methylglyoxal levels also contribute to carbonyl stress, cytotoxicity, DNA damage, apoptosis and cell death. These mechanisms may be important for normal aging of the nervous system as well as for the development of neurodegenerative diseases such as Alzheimer's and Parkinson's disease wher

• br Ca influx through glutamate receptors

  2022-07-14

  

  Ca2+ influx through glutamate receptors is thought to play a critical role in synaptogenesis and in the formation of neuronal circuitry during early development[45]. Because AMPA receptors might contribute to these processes, particularly at times and in cells in which NMDA receptor expression is

• Introduction Glucocorticoids are released in

  2022-07-14

  

  Introduction Glucocorticoids are released in response to stress and play an important role in inflammation, cellular growth, development, body fluid homeostasis, carbohydrate, lipid, and protein metabolism. However, circulating glucocorticoid excess has been associated with a classical phenotype of

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