• In brief while previous studies

  2021-06-22

  

  In brief, while previous studies have evaluated the individual roles of VDR and ER signaling pathways in breast cancer, in the present study we performed an in silico approach for comparative evaluation of these pathways. Considering the complex interaction networks in the context of cancer, such co

• br Experimental Procedures br Acknowledgments br Bisphenol A

  2021-06-22

  

  Experimental Procedures Acknowledgments Bisphenol A (BPA) has been recognized as one of the most potent endocrine disruptors, functioning even at very low doses. Although it is anticipated that p-Cresyl sulfate receptor (ER) would mediate these effects of low-dose BPA, studies revealed that

• Compounds and possessed relatively low

  2021-06-22

  

  Compounds 11–13 and 15 possessed relatively low clogP values and tended to show relatively weak antagonist activity regardless of their potent EP1 receptor affinity. Compounds 2–4, which were selected based on their potent in vivo antagonist activity, were found to be effective in an animal model.

• The endothelin receptor type B EDNRB belongs

  2021-06-21

  

  The endothelin receptor type B (EDNRB) belongs to the family of G protein-coupled receptors, which functions as a vital regulatory factor in signal transduction in cells, locating on human chromosome 13q22.3 (Ayala-Valdovinos et al., 2016; Bregar et al., 2018; Morimoto et al., 2018; Widowati et al.,

• Gene expression profiling with corresponding clinical data s

  2021-06-21

  

  Gene cytochalasin d profiling with corresponding clinical data supported the notion that increased expression of S1PR1 in DLBCL was associated with poor outcome [159], [160], [161]. These studies also identified increased expression of the GPCRs GPR183, CCR7, ADRB2 and CNR2 as risk factors for poor

• Dysfunction of the ubiquitin proteasome

  2021-06-21

  

  Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility [[7], [8], [9]]; this indicates that ubiquitination is essential for spermatogenesis and sperm function during fertilization. β-catenin i

• br Materials and methods br Results br Discussion UPP

  2021-06-21

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important ionomycin of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation syste

• Herein we designed a strategy utilizing the target protectio

  2021-06-21

  

  Herein, we designed a strategy utilizing the target-protection method to produce a signal in a system involving fluorescence CuNPs stabilized by dumbbell template DNA (DT DNA) through a locked circle consisting of two poly T loops and a poly (ATTA) stem. In the presence of MTase, DT DNA was modified

• br Transparency document br Acknowledgments This work was su

  2021-06-21

  

  Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0

• br Neuroimaging Neuroimaging has not yet been systematically

  2021-06-21

  

  Neuroimaging Neuroimaging has not yet been systematically reported in individuals with CDD, although case reports document normal Puromycin aminonucleoside anatomy or less often, show cortical atrophy or T2 fluid-attenuated inversion recovery hyperintensities in the white matter.15, 17, 18, 19,

• ap-1 transcription factor The significant CRF increase in th

  2021-06-21

  

  The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor

• allopurinol zyloprim Assessment of the activity of native an

  2021-06-21

  

  Assessment of the activity of native and denatured TAT-CPG2 after penetration suggests that TAT-CPG2 has been successfully delivered into the cells, and the transduced enzyme is functional inside the cells. The enzyme activity of both native and denatured TAT-fusion proteins in the cultured HepG2 al

• Partial suppression of the cot ts phenotype by deletion of

  2021-06-21

  

  Partial suppression of the cot-1 (ts) phenotype by deletion of gul-1 has been well documented (Seiler et al., 2006). This is now also very clearly evident in the transcriptional profile of the various strains (Fig. 2). Furthermore, the comparative analysis of the single and double mutants revealed,

• Recently pharmacological studies have revealed that natural

  2021-06-21

  

  Recently, pharmacological studies have revealed that natural compounds achieve increasing attention due to its high therapeutic effectiveness and low adverse effect, compared with the chemically synthesized compounds. Emodin is a kind of natural anthraquinone derivative enriched in traditional Chine

• p and p which are downstream

  2021-06-19

  

  p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and isoxsuprine synthesis arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It is wel

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