• ERRGO mice exhibited increased oxygen consumption

  2021-07-21

  

  ERRGO mice exhibited increased oxygen consumption, decreased RER, high running endurance, and resistance to diet-induced weight gain. These changes are physiological hallmarks of increased aerobic capacity in mice and are a direct consequence of engineering highly oxidative and vascularized muscle b

• br Introduction Vein graft implantation

  2021-07-21

  

  Introduction Vein graft implantation into the arterial environment for surgical bypass is the gold standard to treat severe cardiovascular occlusive disease. After placement of a vein into the higher pressure, flow, and oxygen tension of the arterial circulation, the vein adapts to the arterial e

• Altiratinib mg In the present study we investigated the deep

  2021-07-21

  

  In the present study, we investigated the deeper role of eNOS in the pathogenesis of nasal polyps and analyzed the influence of 1,8-cineol on nasal polyp gene and protein expression of eNOS in vitro. Different studies dealt with the localization and expression of eNOS in nasal polyps and nasal mucos

• Signal transduction through IL c

  2021-07-20

  

  Signal transduction through IL-34/ c-FMS ligand receptor also leads to the differentiation, survival and, angiogenesis, proliferation, adhesion and migration of cells of the monocyte/macrophage lineage similar to that of CSF-1 through the various pathways-First is through FAK (Focal Adhesion Kinase)

• Our previous high throughput screening HTS

  2021-07-19

  

  Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based tetracaine hydrochloride assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [

• Mammalian cells contain significant amounts of a relatively

  2021-07-19

  

  Mammalian cells contain significant amounts of a relatively lesser known enzyme that shows marked specifity for ether lipids containing AA and other 20–22 carbon fatty acids. This enzyme is called CoA-independent transacylase (CoA-IT), and transfers polyunsaturated moieties of 20–22 carbons, typical

• br Early developments Historically the advent of SMEPT can b

  2021-07-19

  

  Early developments Historically, the advent of SMEPT can be traced to the 1980′s, where the first example of localized prodrug conversion was achieved using a judiciously placed enzyme – in order to achieve a localized feed of 5-fluorouracil (5-FU). Immobilization of E. coli-derived cytosine deam

• br Funding This work was

  2021-07-19

  

  Funding This work was supported by the PACA Region and Avignon Université. Acknowledgements Introduction Cancer is a pivotal health problem all over the world [1]. In spite of enormous advances achieved in diagnosis and treatment over the past decades, it still accounts for over 22000 deat

• However in many of the above

  2021-07-19

  

  However, in many of the above mentioned studies, the NaCl concentrations in the extraction buffers were different from those used here. For instance, in the study that performed cathepsin D extraction from human AD ripasudil mg tissue, the concentration was 150mM [30], while that for the extraction

• Developmental relationships between CD bright

  2021-07-19

  

  Developmental relationships between CD56bright and CD56dim NK OR-486 remain unresolved; however, several studies indicate that the former is a precursor of the latter. An NK subset with intermediate features between CD56bright and CD56dim has been identified, corroborating this developmental trajec

• ar 165 1 The LNX ligand of numb

  2021-07-19

  

  The LNX (ligand of numb protein-X) or PDZRN (PDZ and RING) family of proteins consists of five members (LNX1–LNX5), the first four of which act as E3‐ubiquitin ligases in various roles, as reviewed elsewhere [14]. LNX proteins comprise a RING domain and two to four PDZ (PSD-95, DlgA, ZO-1) domains [

• LJH685 The data from the Sur lab have showed DNA PK

  2021-07-19

  

  The data from the Sur lab have showed DNA-PK is involved in metabolic gene regulation in response to insulin. DNA-PK regulates fatty LJH685 synthesis by modulating the protein expression of fatty acid synthase (FAS) in a feeding-dependent manner. DNA-PK induces the activation of Upstream Stimulator

• DGK is a key enzyme in glucose

  2021-07-19

  

  DGKδ is a key enzyme in glucose uptake in skeletal muscle. Chibalin et al. demonstrated that a decrease in DGKδ expression increases the severity of type 2 diabetes [20]. Additionally, DGKδ expression was increased in people who exhibited enhanced insulin sensitivity after exercise training [56]. Fr

• br Conclusions The PQQ dependent CcPDH is

  2021-07-19

  

  Conclusions The PQQ-dependent CcPDH is the first PQQ-dependent enzyme identified in eukaryotes. The PQQ cofactor binds the enzyme with high affinity, reflected in a Kd of 1.1 nM, and the enzyme oxidizes 2KG, l-fucose, and rare sugars such as d-arabinose and l-galactose. The AA8 cytochrome b domai

• Moreover recent structural studies of VEEV nsP pro in comple

  2021-07-19

  

  Moreover, recent structural studies of VEEV nsP2pro in complex with E-64d revealed an important molecular interaction at the interface of two subdomains. In this structure, Asn475 which is in polar contact with carbonyl oxygen of Asp507 of the protease subdomain makes an H-bond with Arg662 of the MT

15834 records 638/1056 page Previous Next First page 上5页 636637638639640 下5页 Last page