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br Conclusion As far as we know
2020-07-28
Conclusion As far as we know, this work constituted the first use of silver nitrate staining and sequential FISH in V. vinifera. This technique allowed the unequivocal identification of Ag-NORs and corresponding rDNA loci. Besides, silver nitrate staining and sequential FISH may bring new insigh
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Nitroacrylate derivatives and were as active if not
2020-07-28
Nitroacrylate derivatives and were as active, if not more so, than cyanoacrylate and malonate derivatives , and ,. As discussed above, we considered that the conformational preferences in the polar ‘head group’ would be important in determining the binding mode of these inhibitors to DHODH, and so
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CysLT receptors are expressed on a variety of peripheral
2020-07-28
CysLT receptors are expressed on a variety of peripheral blood leukocytes, but of interest, they are also expressed on cells that synthesize LTC, such as eosinophils and mast cells. The expression of cysLT receptors has not been evaluated on basophils, and efforts to do this have been hampered by th
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In astrocytes mitogen activated protein kinases MAPKs are
2020-07-28
In astrocytes, mitogen-activated protein kinases (MAPKs) are activated after OGD-induced ischemic injury (Yung and Tolkovsky, 2003, Niu et al., 2009) and they regulate induction of AQP expression (Arima et al., 2003, McCoy and Sontheimer, 2010). It is well known that MAPKs, including extracellular s
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[Ala92]-p16 (84-103) Intra dPAG injections of CRF also
2020-07-28
Intra-dPAG injections of CRF also reduced the nociceptive response induced by formalin injection into the hind paw. CRF-treated animals showed a reduction in the time spent on licking the formalin-injected paw, characterizing an antinociceptive role played by this neuropeptide in the mouse PAG. Pres
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fmoc osu synthesis Several findings are now further
2020-07-28
Several findings are now further reinforcing the critical role played by the zinc-metalloprotease gp63 as a virulence factor that greatly influence host cell signaling mechanisms and related functions. Thus the status of gp63 has reached the level of a multifunctional protein; consequently, it is po
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br Application of the BN Cox model to risk
2020-07-28
Application of the BN-Cox model to risk calculation As we mentioned earlier, CPH models are widely used in medical risk assessment and are often reported in the literature. Recently, we proposed a BN-Cox-based risk score calculator to the existing Pulmonary Arterial Hypertension (PAH) risk calcul
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br The recommendation process The recommendation
2020-07-28
The recommendation process The recommendation process consists of four phases as illustrated in Fig. 7, namely query expansion, COTS components repository filtering, COTS components retrieval, and results ranking and display. The user triggers the process by submitting a query composed of a set o
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Fmoc-D-Phe(4-Cl)-OH In conclusion our findings suggest that
2020-07-28
In conclusion, our findings suggest that the G allele of COMT rs6269 and the high-COMT activity haplotype (G_C_C_G for rs6269, rs4633, rs4818, and rs4680) are associated with the change in global cognitive function in our PD patients. A long-term longitudinal follow-up study is required to confirm o
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Their action is based on esterification of a serine hydroxyl
2020-07-28
Their action is based on esterification of a serine hydroxyl group found in the active center of the AChE [7]. This results in modification of the AChE, leaving it without its biological role and effectively preventing the enzyme from breaking down the Carbetocin synthesis molecule. Accumulation of
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br Introduction Cardiovascular heart disease CHD
2020-07-28
Introduction Cardiovascular heart disease (CHD) is the leading cause of death worldwide [1]. One of the major risk factors for CHD are elevated serum cholesterol concentrations [2]. Lowering the level of serum cholesterol is an established clinical practice for CHD treatment, intervention, and pr
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The individuals described here experienced corneal vasculari
2020-07-27
The individuals described here experienced corneal vascularization in early adult life. DDR2 is able to both drive and prevent angiogenesis under different conditions.21, 22, 23 The primary effect seems to be angiogenesis stimulation, but a rebound effect or overcompensation can counterbalance this.
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Overall the DDR kinase domain has a
2020-07-27
Overall, the DDR1 kinase domain has a typical kinase domain structure and adequate sequence and/or structure similarity with other kinase domains, as shown in Fig. 2, which allow homology modeling of the active and inactive conformations. In addition to conformational changes to the activation loop
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br Materials and methods br Results
2020-07-27
Materials and methods Results Discussion We found that CysLT2 receptors were constitutively expressed in bronchial smooth muscle cells, and that CysLT2 receptor-expressing leukocytes, mainly consisting of macrophage/dendritic cells and eosinophils, infiltrated into the lung after multiple a
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br Materials and methods br Results The i v
2020-07-27
Materials and methods Results The i.v. administration of urocortin 2 reduced the mean arterial blood pressure in a dose-dependent manner (Fig. 1). The ED50 for the urocortin 2 cumulative dose–response effect on mean arterial blood pressure was 0.014±0.004 mg kg−1. Urocortin 2 administration ha
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